Impaired inhibitory control of cortical synchronization in fragile X syndrome
نویسندگان
چکیده
منابع مشابه
Impaired inhibitory control of cortical synchronization in fragile X syndrome.
Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by severe cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy. Fmr1 knockout (KO) mouse models of FXS exhibit alterations in excitatory and inhibitory neurotransmission, but it is largely unknown how aberrant function of specific neuronal subtypes contributes to these deficits. In thi...
متن کاملImpaired inhibitory control of cortical synchronization in fragile x
24 Fragile X Syndrome (FXS) is a neurodevelopmental disorder characterized by severe 25 cognitive impairments, sensory hypersensitivity, and comorbidities with autism and epilepsy. 26 Fmr1 knockout (KO) mouse models of FXS exhibit alterations in excitatory and inhibitory 27 neurotransmission, but it is largely unknown how aberrant function of specific neuronal subtypes 28 contributes to these d...
متن کاملCortical neurogenesis in fragile X syndrome.
The absence of fragile X mental retardation 1 protein (FMRP) results in fragile X syndrome (FXS) that is a common cause of intellectual disability and a variant of autism spectrum disorder. There is evidence that FMRP is involved in neurogenesis. FMRP is widely expressed throughout the embryonic brain development and its expression levels increases during neuronal differentiation. Cortical neur...
متن کاملNeural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome
BACKGROUND Studies in the fmr1 KO mouse demonstrate hyper-excitability and increased high-frequency neuronal activity in sensory cortex. These abnormalities may contribute to prominent and distressing sensory hypersensitivities in patients with fragile X syndrome (FXS). The current study investigated functional properties of auditory cortex using a sensory entrainment task in FXS. METHODS EEG...
متن کاملEye movements reveal impaired inhibitory control in adult male fragile X premutation carriers asymptomatic for FXTAS.
OBJECTIVE Fragile X premutation carriers (fXPCs) have an expansion of 55-200 CGG repeats in the FMR1 gene. Male fXPCs are at risk for developing a neurodegenerative motor disorder (FXTAS) often accompanied by inhibitory control impairments, even in fXPCs without motor symptoms. Inhibitory control impairments might precede, and thus indicate elevated risk for motor impairment associated with FXT...
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ژورنال
عنوان ژورنال: Journal of Neurophysiology
سال: 2011
ISSN: 0022-3077,1522-1598
DOI: 10.1152/jn.00421.2011